The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Nov. 28, 2014
Applicant:
Evotec International Gmbh, Hamburg, DE;
Inventors:
Joerg Kley, Ingelheim am Rhein, DE;
Andreas Blum, Ingelheim am Rhein, DE;
Dirk Gottschling, Ingelheim am Rhein, DE;
Joerg P. Hehn, Ingelheim am Rhein, DE;
Dieter Wiedenmayer, Ingelheim am Rhein, DE;
Assignee:
EVOTEC INTERNATONAL GMBH, , DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 401/12 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/517 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01);
Abstract
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula (I), wherein Ar, Rand Rare as defined in the description and claims, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.