The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Jun. 25, 2014
Applicants:
Universita' Degli Studi Di Siena, Siena (SI), IT;
Universita' Degli Studi Di Roma “la Sapienza”, Rome (RM), IT;
Inventors:
Bruno Botta, Rome, IT;
Alberto Gulino, Rome, IT;
Maurizio Botta, Siena, IT;
Mattia Mori, Rome, IT;
Lucia Di Marcotullio, Rome, IT;
Paola Infante, Rome, IT;
Francesca Ghirga, Rome, IT;
Sara Toscano, Rome, IT;
Cinzia Ingallina, Rome, IT;
Romina Alfonsi, Rome, IT;
Assignees:
UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”, Rome (RM), IT;
UNIVERSITA DEGLI STUDI DI SIENA, Siena (SI), IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/34 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 45/06 (2006.01); A61K 31/352 (2006.01); A61K 31/121 (2006.01); A61K 31/343 (2006.01); A61K 31/35 (2006.01);
U.S. Cl.
CPC ...
C07D 311/34 (2013.01); A61K 9/0019 (2013.01); A61K 9/127 (2013.01); A61K 31/121 (2013.01); A61K 31/343 (2013.01); A61K 31/35 (2013.01); A61K 31/352 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).