The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Jul. 23, 2014
Applicant:
Avexxin As, Trondheim, NO;
Inventors:
Marcel Sanderberg, Oslo, NO;
Inger-Reidun Aukrust, Oslo, NO;
Assignee:
Avexxin AS, Trondheim, NO;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 319/14 (2006.01); C07C 319/26 (2006.01); C07C 319/02 (2006.01); C07C 327/22 (2006.01);
U.S. Cl.
CPC ...
C07C 319/14 (2013.01); C07C 319/02 (2013.01); C07C 319/26 (2013.01); C07C 327/22 (2013.01);
Abstract
The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acceptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.