The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 09, 2018

Filed:

Apr. 11, 2014
Applicant:

Mangogen Pharma Inc., Laval, CA;

Inventors:

Satya Prakash, Brossard, CA;

Arghya Paul, Longueuil, CA;

Dominique Shum-Tim, Beaconsfield, CA;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/01 (2006.01); A61K 35/76 (2015.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); A61K 38/19 (2006.01); C12N 7/00 (2006.01); A61K 9/50 (2006.01); A61K 38/36 (2006.01); A61L 31/12 (2006.01); A61L 31/14 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/76 (2013.01); A61K 9/5031 (2013.01); A61K 9/5089 (2013.01); A61K 38/19 (2013.01); A61K 38/36 (2013.01); A61K 38/363 (2013.01); A61L 31/10 (2013.01); A61L 31/125 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C12N 7/00 (2013.01); A61K 48/00 (2013.01); A61L 2300/414 (2013.01); A61L 2300/418 (2013.01); A61L 2300/622 (2013.01); A61L 2430/34 (2013.01); C12N 2710/14032 (2013.01); C12N 2710/14043 (2013.01); C12N 2710/14143 (2013.01);
Abstract

The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.


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