The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
May. 04, 2017
Applicant:
King Fahd University of Petroleum and Minerals, Dhahran, SA;
Inventors:
Muhammad Altaf, Dhahran, SA;
Muhammad Monim-Ul-Mehboob, Dhahran, SA;
Anvarhusein Abdulkadir Isab, Dhahran, SA;
Saleh Altuwaijri, AlKhobar, SA;
Assignee:
King Fahd University of Petroleum and Minerals, Dhahran, SA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/66 (2006.01); A61K 31/404 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/44 (2006.01); A61K 33/24 (2006.01); A61K 39/395 (2006.01); C07F 1/12 (2006.01); C07F 9/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/66 (2013.01); A61K 31/404 (2013.01); A61K 31/44 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 33/24 (2013.01); A61K 39/395 (2013.01); A61K 39/39558 (2013.01); C07F 1/12 (2013.01); C07F 9/5045 (2013.01);
Abstract
Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.