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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10092566 B1

PDFFull Text
Date of Patent:
Oct. 09, 2018

Filed:

May. 08, 2014

Composition for controlling a gut immunity and use thereof

Applicant:

Seoul National University R&db Foundation, Seoul, KR;

Inventor:

Won Jae Lee, Seoul, KR;

Assignee:

SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul, KR;

Attorney:

Norton Rose Fulbright US LLP

Primary Examiner:

Zohreh A Fay

Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 31/01 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 31/355 (2006.01); A61K 31/375 (2006.01); A61K 31/409 (2006.01); A61K 31/522 (2006.01); A61K 45/06 (2006.01); A61K 31/505 (2006.01); A61K 31/7072 (2006.01); G06F 17/30 (2006.01); A23L 33/10 (2016.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A23L 33/10 (2016.08); A61K 31/01 (2013.01); A61K 31/352 (2013.01); A61K 31/353 (2013.01); A61K 31/355 (2013.01); A61K 31/375 (2013.01); A61K 31/409 (2013.01); A61K 31/505 (2013.01); A61K 31/522 (2013.01); A61K 31/7072 (2013.01); A61K 45/06 (2013.01); G06F 17/30598 (2013.01);
Abstract

The present invention relates to an antimicrobial composition for uracil non-secretory (URA−) bacteria, comprising uracil, uracil precursors, uracil analogs, or uracil-secreting opportunistic pathogens as an active ingredient; and a composition for preventing cell damage caused by uracil-secretory (URA+) bacteria, comprising ROS scavengers as an active ingredient. The present invention also relates to food or feed for antimicrobial activity and preventing cell damage, comprising said composition; a method for controlling dual oxidase (DUOX) activation, the generation of reactive oxygen species (ROS), or the level thereof; a method for producing cells, wherein DUOX activation, the generation of ROS, or the level thereof are controlled; and a method for providing information on gut pathogenicity in isolated bacteria. The composition of the present invention has effects for preventing symptoms caused by bacteria according to a mechanism which has been unknown in the art. Further, the present invention can be efficiently utilized for establishing prevention and treatment strategies for symptoms caused by bacteria later, as therapeutic strategies can be readily established by bacterial classification based on criteria that can be easily confirmed.

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