The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Nov. 20, 2017
Applicants:
Vincent Tam, Bellaire, TX (US);
Diana Chow, Houston, TX (US);
Jie Gohlke, Houston, TX (US);
Inventors:
Assignee:
University of Houston System, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/00 (2006.01); A61K 47/28 (2006.01); A61K 47/24 (2006.01); A61K 38/12 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 9/0019 (2013.01); A61K 38/12 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01);
Abstract
The present invention provides an intravenous liposomal formulation of a low dose polymyxin B or a pharmaceutical composition thereof. The present invention also provides methods utilizing the intravenous liposomal formulation or its pharmaceutical composition for increasing the therapeutic efficacy during treatment of a bacterial infection in a subject, for decreasing exposure of renal tissue to the polymyxin B during a course of polymyxin B treatment and for lowering exposure to polymyxin B in renal tissues in a subject receiving polymyxin B treatment.