The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Mar. 17, 2016
Applicant:
Yale University, New Haven, CT (US);
Inventor:
Richard Leslie Edelson, Westport, CT (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0784 (2010.01); A61M 1/34 (2006.01); A61M 1/36 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0639 (2013.01); A61M 1/3496 (2013.01); A61M 1/3681 (2013.01); A61M 1/3683 (2014.02); C12N 5/064 (2013.01); A61M 1/3693 (2013.01); A61M 2202/0415 (2013.01); A61M 2205/12 (2013.01); C12N 2500/02 (2013.01); C12N 2501/998 (2013.01); C12N 2502/11 (2013.01); C12N 2506/115 (2013.01); C12N 2521/00 (2013.01);
Abstract
Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins. The leukocyte concentrate comprising monocytes and plasma containing proteins is pumped through a plastic treatment device, such as a photopheresis device. The resulting treated cells may be incubated for a sufficient period of time to allow the monocytes to form dendritic cells, or the treated cells may be reinfused directly to the subject.