The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 02, 2018

Filed:

Mar. 11, 2016
Applicant:

Complix SA, Luxembourg, LU;

Inventors:

Johan Desmet, Kortrijk, BE;

Ignace Lasters, Antwerp, BE;

Maria Henderikx, Hasselt, BE;

Anita Wehnert, Boorsem-Maasmechelen, BE;

Assignee:

COMPLIX SA, Luxembourg, LU;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); C07K 16/24 (2006.01); C07K 14/00 (2006.01); C12N 15/10 (2006.01); C07K 16/00 (2006.01); C40B 50/12 (2006.01);
U.S. Cl.
CPC ...
C07K 16/244 (2013.01); C07K 14/001 (2013.01); C07K 16/00 (2013.01); C07K 16/005 (2013.01); C12N 15/1037 (2013.01); C12N 15/1055 (2013.01); C07K 2317/33 (2013.01); C07K 2318/20 (2013.01); C40B 40/10 (2013.01); C40B 50/12 (2013.01);
Abstract

The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.


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