The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Jan. 28, 2015
F. Hoffmann-la Roche Ag, Basel, CH;
Institut Pasteur, Paris, FR;
Commissariat a L'energie Atomique ET Aux Energies Alternatives, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Pierre Lafaye, Malakoff, FR;
Sylvie Bay, Paris, FR;
Benoit Delatour, Cachan, FR;
Marc Dhenain, Limours, FR;
Charles Duyckaerts, Saint-mande, FR;
Tengfei Li, Courbevoie, FR;
Matthias Vandesquille, Fontenay-aux-roses, FR;
Christian Czech, Grenzach-wyhlen, DE;
Fiona Grueninger, Arlesheim, CH;
F. HOFFMANN-LA ROCHE AG, Basel, CH;
INSTITUT PASTEUR, Paris, FR;
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Abstract
The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.