The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
May. 02, 2017
New York University, New York, NY (US);
Janssen Biotech, Inc., Horsham, PA (US);
Victor J. Torres, New York, NY (US);
Randall J. Brezski, Alameda, CA (US);
Anthony Lynch, Spring House, PA (US);
William Strohl, Spring House, PA (US);
Brian Whitaker, Spring House, PA (US);
Mark Chiu, Spring House, PA (US);
Peter T. Buckley, Spring House, PA (US);
Keri Dorn, Spring House, PA (US);
Michelle Kinder, Spring House, PA (US);
New York University, New York, NY (US);
Janssen Biotech, Inc., Horsham, PA (US);
Abstract
The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of ainfection, including methicillin-resistant