The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Apr. 27, 2016
Applicant:
Ku Leuven Research & Development;
Inventors:
Piet Herdewijn, Heverlee, BE;
Steven De Jonghe, Tervuren, BE;
Shrivinas Dumbre, Leuven, BE;
Chao Liu, Heverlee, BE;
Assignee:
KU LEUVEN RESEARCH & DEVELOPMENT, Leuven, BE;
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/10 (2006.01); C07H 19/20 (2006.01); A61K 31/7076 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 31/708 (2006.01); A61K 31/7072 (2006.01); A61K 31/7068 (2006.01); A61P 31/20 (2006.01);
U.S. Cl.
CPC ...
C07H 19/20 (2013.01); A61K 31/708 (2013.01); A61K 31/7068 (2013.01); A61K 31/7072 (2013.01); A61K 31/7076 (2013.01); A61K 45/06 (2013.01); A61P 31/20 (2018.01); A61P 35/00 (2018.01); C07H 19/10 (2013.01);
Abstract
The present invention relates to novel pro-drugs of L-2'-deoxythreose nucleoside phosphonates, such as phosphoramidate, phosphorodiamidate and phospho-diester pro-drugs. The invention also relates to a process for preparing these novel prodrugs of nucleoside phosphonates. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the HBV family.