The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 02, 2018

Filed:

Jul. 05, 2016
Applicant:

Synthetic Genomics, Inc., La Jolla, CA (US);

Inventors:

Spiros Kambourakis, San Diego, CA (US);

Benjamin M. Griffin, San Diego, CA (US);

Assignee:

Synthetic Genomics, Inc., La Jolla, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/46 (2006.01); C07D 307/40 (2006.01); C07D 307/68 (2006.01); C12P 17/04 (2006.01); C12P 7/58 (2006.01);
U.S. Cl.
CPC ...
C07D 307/68 (2013.01); C12P 7/58 (2013.01); C12P 17/04 (2013.01);
Abstract

The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve performing a chemical dehydration reaction on a gluconic acid derivative in the presence of a dehydration catalyst. In some embodiments the gluconic acid derivative can be 2-dehydro-3-deoxy gluconic acid (DHG) or an ester thereof, 2-ketogluconic acid (2KGA) or an ester thereof, and 5-ketogluconic acid (5KGA) or an ester thereof. The 2,5-furan dicarboxylic acid precursor molecule is thereby synthesized, which can be converted into FDCA. The chemical dehydration can be performed by a variety of acid basic catalysts.


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