The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Jan. 24, 2014
Applicants:
Trustees of Boston University, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Aaron Beaty Beeler, Cambridge, MA (US);
John A. Porco, Jr., Brookline, MA (US);
Oscar J. Ingham, Boston, MA (US);
James E. Bradner, Weston, MA (US);
Assignees:
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 249/06 (2006.01); A61K 31/4192 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 249/06 (2013.01); A61K 31/4192 (2013.01); A61K 45/06 (2013.01);
Abstract
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that benefit from inhibition of HDAC8 activity.