The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Jan. 22, 2016
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
The Johns Hopkins University, Baltimore, MD (US);
Joel Schneider, Middletown, MD (US);
Gerald Brandacher, Baltimore, MD (US);
Daniel Smith, West Chester, PA (US);
Gabriel Brat, Baltimore, MD (US);
Johanna Grahammer, Innsbruck, AT;
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. The peptides comprise photo-caged glutamate residues with a neutral photocage that can be photolytically selectively uncaged to disrupt the fibrillar network and trigger an irreversible gel-sol phase transition of the hydrogel. Isolated peptides for making the disclosed hydrogels are provided, as are methods of using the peptide hydrogels in anastomosis procedures.