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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10086093 B1

PDFFull Text
Date of Patent:
Oct. 02, 2018

Filed:

Feb. 26, 2014

Mirna profiling compositions and methods of use

Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Anna V. Moore, Dracut, MA (US);

Zdravka Medarova, Methuen, MA (US);

Assignee:

THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);

Attorneys:

Nixon Peabody LLP

David S. Resnick

Shayne Y. Huff

Primary Examiner:

Robert T Crow

Int. Cl.
CPC ...
C12Q 1/68 (2018.01); A61K 49/10 (2006.01); C12N 15/11 (2006.01); C12Q 1/6825 (2018.01); C12Q 1/6886 (2018.01); C12Q 1/6818 (2018.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/10 (2013.01); C12N 15/111 (2013.01); C12Q 1/6818 (2013.01); C12Q 1/6825 (2013.01); C12Q 1/6886 (2013.01); A61K 9/0019 (2013.01); C12N 2310/141 (2013.01); C12N 2320/10 (2013.01); C12Q 2525/207 (2013.01); C12Q 2545/114 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01);
Abstract

Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a delivery particle comprising an iron oxide crystal coated with a polymer; and a sensor oligonucleotide covalently attached to the polymer. The sensor oligonucleotide comprises a seed region, comprising a nucleic acid sequence that is completely complementary to the target miRNA and comprises a cleavage site which can be engaged and cleaved by the target miRNA.

Find Patent Forward Citations

Moore, Anna. (2018). Mirna profiling compositions and methods of use (U.S. Patent No. 10086093). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10086093

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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