The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Jan. 26, 2015
Applicant:
Pfizer Inc., New York, NY (US);
Inventors:
Andreas Maderna, Stony Point, NY (US);
Matthew David Doroski, Mystic, CT (US);
Zecheng Chen, New City, NY (US);
Hud Lawrence Risley, Baltic, CT (US);
Jeffrey Michael Casavant, Franklin, CT (US);
Christopher John O'Donnell, Mystic, CT (US);
Alexander M. Porte, Madison, CT (US);
Chakrapani Subramanyam, South Glastonbury, CT (US);
Assignee:
Pfizer Inc., New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 487/06 (2006.01); C07D 209/30 (2006.01); A61K 31/404 (2006.01); A61K 31/407 (2006.01); A61K 47/48 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/675 (2006.01); A61K 31/7056 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07F 9/6561 (2006.01); C07H 17/02 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 9/00 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
A61K 47/48384 (2013.01); A61K 31/404 (2013.01); A61K 31/407 (2013.01); A61K 31/433 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/675 (2013.01); A61K 31/7056 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 47/6803 (2017.08); A61K 47/6807 (2017.08); A61K 47/6811 (2017.08); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07F 9/6561 (2013.01); C07H 17/02 (2013.01); C07K 5/06 (2013.01); C07K 5/08 (2013.01); C07K 9/003 (2013.01);
Abstract
Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.