The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2018
Filed:
Mar. 13, 2017
Abbvie Inc., North Chicago, IL (US);
Chengbin Wu, Shanghai, CN;
Richard W. Dixon, Jefferson, MA (US);
Jonathan P. Belk, Grantham, NH (US);
Hua Ying, Holden, MA (US);
Maria A. Argiriadi, Southborough, MA (US);
Carolyn A. Cuff, Grafton, MA (US);
Paul R. Hinton, Sunnyvale, CA (US);
Shankar Kumar, Pleasanton, CA (US);
Terry L. Melim, Derry, NH (US);
Yan Chen, Alameda, CA (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.