The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 25, 2018

Filed:

Oct. 26, 2016
Applicant:

Icagen, Inc., Durham, NC (US);

Inventors:

Benjamin P. Warner, Los Alamos, NM (US);

Lori J. Peterson, Los Alamos, NM (US);

Jennifer A. Berger, Los Alamos, NM (US);

Eva R. Birnbaum, Los Alamos, NM (US);

Rebecca L. E. Miller, Los Alamos, NM (US);

Assignee:

ICAGEN, INC., Durham, NC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 23/223 (2006.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); G01N 23/207 (2018.01);
U.S. Cl.
CPC ...
G01N 33/6872 (2013.01); G01N 23/2076 (2013.01); G01N 23/223 (2013.01); G01N 33/502 (2013.01); G01N 2223/076 (2013.01);
Abstract

The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.


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