The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
Aug. 18, 2017
Shenzhen Institutes of Advanced Technology, Shenzhen, Guangdong, CN;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Qingguo Ruan, Guangdong, CN;
Youhai H. Chen, Philadelphia, PA (US);
Tingting Fan, Guangdong, CN;
Yifan Ma, Guangdong, CN;
Lintao Cai, Guangdong, CN;
Shaowen Wang, Guangdong, CN;
Xiaochun Wan, Guangdong, CN;
SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, Shenzhen, Guangdong, CN;
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Abstract
The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.