The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
May. 16, 2012
Applicants:
John Chaddock, Abingdon, GB;
Elaine Harper, Abingdon, GB;
Inventors:
John Chaddock, Abingdon, GB;
Elaine Harper, Abingdon, GB;
Assignee:
Ipsen Bioinnovation Limited, Abingdon, Oxfordshire, GB;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12N 9/88 (2006.01); C12N 1/20 (2006.01); C12N 15/00 (2006.01); C12P 21/04 (2006.01); C12P 21/06 (2006.01); C07H 21/04 (2006.01); A61K 38/43 (2006.01); C07K 1/00 (2006.01); C12N 9/96 (2006.01); C07K 7/18 (2006.01); C07K 7/23 (2006.01); C07K 14/575 (2006.01); C12N 9/52 (2006.01); C12N 15/62 (2006.01); C07K 14/60 (2006.01); C12N 9/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); C07K 7/18 (2013.01); C07K 7/23 (2013.01); C07K 14/575 (2013.01); C07K 14/57572 (2013.01); C07K 14/60 (2013.01); C12N 9/50 (2013.01); C12N 9/52 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/06 (2013.01); C07K 2319/21 (2013.01); C07K 2319/50 (2013.01); C07K 2319/74 (2013.01);
Abstract
The present invention relates to the construction of a new class of Targeted Secretion Inhibitors (TSIs), which comprise a non-cytotoxic protease, translocation peptide and a targeting moiety peptide, wherein the targeting moiety peptide has a free N-terminal domain and a free C-terminal domain; to a single-chain fusion protein precursor thereof, and to a method of activating said single-chain fusion protein precursor.