The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
Aug. 02, 2013
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Assignee:
Yeda Research and Development Co., Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/12 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12N 5/16 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/10 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C07K 14/70503 (2013.01); A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C12N 15/102 (2013.01);
Abstract
The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.