The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 25, 2018

Filed:

Apr. 06, 2016
Applicants:

The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Washington, DC (US);

University of Florida Research Foundation, Inc., Gainesville, FL (US);

Inventors:

John A. Chiorini, Dayton, MD (US);

Sandra Wainer, Bethesda, MD (US);

Mavis Agbandje-McKenna, Gainesville, FL (US);

Sujata Halder, Gainesville, FL (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/005 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 48/0008 (2013.01); A61K 48/0075 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2810/6027 (2013.01);
Abstract

A modified adeno-associated virus (AAV) capsid protein comprising at least one non-native amino acid that confers to the modified AAV particles new properties, such as increased transduction efficiency and reduced immunogenicity. These modified AAV proteins and particles are particularly useful for gene therapy and the treatment of various diseases and conditions.


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