The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
Apr. 11, 2016
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Eric Mertz, Christianburg, VA (US);
Scott D. Edmondson, Concord, MA (US);
Sung-Sau So, Verona, NJ (US);
Wanying Sun, Edison, NJ (US);
Weiguo Liu, Princeton, NJ (US);
Santhosh F. Neelamkavil, Edison, NJ (US);
Ying-Duo Gao, Holmdel, NJ (US);
Alan Hruza, Hackettstown, NJ (US);
Yi Zang, Princeton Junction, NJ (US);
Amjad Ali, Freehold, NJ (US);
Rudrajit Mal, Piscataway, NJ (US);
Jiafang He, South Brunswick, NJ (US);
Rongze Kuang, Green Brook, NJ (US);
Heping Wu, Edison, NJ (US);
Anthony K. Ogawa, New Providence, NJ (US);
Andrew F. Nolting, Trenton, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.