The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 25, 2018

Filed:

Mar. 14, 2014
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Sangeeta Bhatia, Lexington, MA (US);

Jing Shan, Cambridge, MA (US);

Michelle Palmer, Harvard, MA (US);

Nathan Ross, Cambridge, MA (US);

Assignees:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C07D 263/24 (2006.01); C12N 5/071 (2010.01); A01K 67/027 (2006.01); A61K 31/137 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/4174 (2006.01); A61K 31/4409 (2006.01); A61K 35/407 (2015.01); C07C 211/32 (2006.01); C07D 209/48 (2006.01); C07D 209/88 (2006.01); C07D 213/75 (2006.01);
U.S. Cl.
CPC ...
C07D 263/24 (2013.01); A01K 67/0278 (2013.01); A61K 31/137 (2013.01); A61K 31/403 (2013.01); A61K 31/4035 (2013.01); A61K 31/4174 (2013.01); A61K 31/4409 (2013.01); A61K 35/407 (2013.01); C07C 211/32 (2013.01); C07D 209/48 (2013.01); C07D 209/88 (2013.01); C07D 213/75 (2013.01); C12N 5/067 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C12N 2501/02 (2013.01); C12N 2501/115 (2013.01); C12N 2501/12 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/237 (2013.01); C12N 2501/999 (2013.01); C12N 2503/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/90 (2013.01); Y02A 50/387 (2018.01); Y02A 50/463 (2018.01);
Abstract

The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.


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