The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
Mar. 25, 2013
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Paul J. Hergenrother, Champaign, IL (US);
Robert W. Huigens, Iii, Gainesville, FL (US);
Karen C. Morrison, Champaign, IL (US);
Robert W. Hicklin, Ii, Urbana, IL (US);
Timothy A. Flood, Jr., Champaign, IL (US);
Paul J. Hergenrother, Champaign, IL (US);
Robert W. Huigens, III, Gainesville, FL (US);
Karen C. Morrison, Champaign, IL (US);
Robert W. Hicklin, II, Urbana, IL (US);
Timothy A. Flood, Jr., Champaign, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of spcarbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.