The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 25, 2018

Filed:

Jun. 14, 2017
Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Julie Di Paolo, San Francisco, CA (US);

Astrid Clarke, Bainbridge Island, WA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/475 (2006.01); A61K 45/06 (2006.01); A61K 31/4985 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/475 (2013.01); A61K 31/4985 (2013.01); A61K 45/06 (2013.01);
Abstract

Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer and may not respond to either agent administered as a sole therapy. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma, or a solid tumor cancer, such as pancreatic, lung and colon cancer.


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