The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2018
Filed:
Sep. 06, 2013
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Derrick J. Rossi, Roslindale, MA (US);
Roi Gazit, Brookline, MA (US);
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A61K 48/00 (2006.01); C07H 21/04 (2006.01); C12Q 1/6897 (2018.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C12Q 1/6897 (2013.01); G01N 33/5073 (2013.01); A01K 67/0275 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/02 (2013.01); C07H 21/04 (2013.01); C12N 2517/02 (2013.01);
Abstract
Described herein are nucleic acid constructs, hematopoietic stem cell identifier animals, and methods of using thereof for isolating hematopoietic stem cell populations. Also provided are methods of using the identifier animals and cells isolated from them to screen for agents that affect the growth, proliferation, potency, expansion, or maintenance of the stem cells. Such agents can be used for promoting growth of stem cells in vitro or in vivo, and also for inhibiting cancer cells that have been determined to resemble a stem cell.