The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Dec. 23, 2016
Case Western Reserve University, Cleveland, OH (US);
Anant Madabhushi, Shaker Heights, OH (US);
Xiangxue Wang, Cleveland, OH (US);
Vamsidhar Velcheti, Pepper Pike, OH (US);
German Corredor Prada, Bogota, CO;
Case Western Reserve University, Cleveland, OH (US);
Abstract
Methods and apparatus predict non-small cell lung cancer (NSCLC) recurrence using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue demonstrating NSCLC. One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating NSCLC, a segmentation circuit that segments a cellular nucleus from the image, a feature extraction circuit that extracts a set of features from the image, a tumor infiltrating lymphocyte (TIL) identification circuit that classifies the segmented nucleus as a TIL or non-TIL, a graphing circuit that constructs a TIL graph and computes a set of TIL graph statistical features, and a classification circuit that computes a probability that the region will experience NSCLC recurrence. The classification circuit may compute a quantitative continuous image-based risk score based on the probability or the image. A treatment plan may be provided based on the risk score.