The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 18, 2018

Filed:

May. 17, 2013
Applicants:

Dh Technologies Development Pte. Ltd., Singapore, SG;

Oregon Health and Science University, Portland, OR (US);

Inventors:

Andrea DeBarber, Vancouver, WA (US);

Subhasish Purkayastha, Acton, MA (US);

Robert D. Steiner, Portland, MA (US);

Michal Weinstock, Newton, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); G01N 33/92 (2006.01); G01N 33/58 (2006.01); H01J 49/00 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/92 (2013.01); G01N 33/58 (2013.01); G01N 33/6848 (2013.01); G01N 33/6893 (2013.01); H01J 49/0031 (2013.01); G01N 2333/90251 (2013.01); G01N 2400/00 (2013.01); G01N 2800/04 (2013.01); G01N 2800/065 (2013.01); G01N 2800/385 (2013.01);
Abstract

A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for Cerebrotendinous Xanthomatosis (CTX). Methods for labeling, analyzing, and quantifying ketosterol biomarkers are also disclosed as are methods that also use mass spectrometry.


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