The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 18, 2018

Filed:

Dec. 10, 2012
Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

John P. Wikswo, Brentwood, TN (US);

David E. Cliffel, Nashville, TN (US);

Dmitry A. Markov, Nashville, TN (US);

John A. McLean, Nashville, TN (US);

Lisa Joy McCawley, Nashville, TN (US);

Phillip C. Samson, Nashville, TN (US);

Ronald S. Reiserer, Nashville, TN (US);

Frank Emmanuel Block, Nashville, TN (US);

Jennifer Robin McKenzie, Nashville, TN (US);

Assignee:

VANDERBILT UNIVERSITY, Nashville, TN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); B01L 3/00 (2006.01); G01N 35/10 (2006.01); A01N 1/02 (2006.01); C12M 3/06 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5005 (2013.01); A01N 1/0247 (2013.01); B01L 3/5027 (2013.01); G01N 35/1095 (2013.01); B01L 3/502715 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0877 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0622 (2013.01); C12M 23/16 (2013.01);
Abstract

In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.


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