The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 18, 2018

Filed:

Jan. 14, 2016
Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Adam E. Cohen, Cambridge, MA (US);

Miao-Ping Chien, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12Q 1/24 (2006.01); C07D 207/46 (2006.01); C07D 495/04 (2006.01); G01N 21/64 (2006.01); G01N 33/58 (2006.01); C09B 23/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/24 (2013.01); C07D 207/46 (2013.01); C07D 495/04 (2013.01); C09B 23/00 (2013.01); C12N 5/0006 (2013.01); C12N 5/0081 (2013.01); G01N 21/6428 (2013.01); G01N 33/5026 (2013.01); G01N 33/582 (2013.01); G01N 2021/6439 (2013.01);
Abstract

Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.


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