The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Jun. 12, 2014
Applicant:
Technical University of Denmark, Kgs. Lyngby, DK;
Inventors:
Kanchana Rueksomtawin Kildegaard, Kgs. Lyngby, DK;
Irina Borodina, Kgs. Lyngby, DK;
Jochen Förster, Kgs. Lyngby, DK;
Jens Nielsen, Kgs. Lyngby, DK;
Assignee:
TECHNICAL UNIVERSITY OF DENMARK, Kgs. Lyngby, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/00 (2006.01); C12P 7/42 (2006.01); C12N 9/04 (2006.01); C12P 7/52 (2006.01);
U.S. Cl.
CPC ...
C12P 7/42 (2013.01); C12N 9/0006 (2013.01); C12P 7/52 (2013.01); C12Y 101/01284 (2013.01);
Abstract
Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.