The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Jun. 05, 2014
Applicant:
Galderma S.a., Cham, CH;
Inventors:
Morgan Karlsson, Knivsta, SE;
Katarina Edsman, Alunda, SE;
Assignee:
GALDERMA S.A., Cham, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08B 37/08 (2006.01); C08J 3/075 (2006.01); C08J 3/24 (2006.01); A61K 9/06 (2006.01); A61K 8/04 (2006.01); A61Q 19/00 (2006.01); A61K 8/73 (2006.01); A61K 31/728 (2006.01);
U.S. Cl.
CPC ...
C08B 37/0072 (2013.01); A61K 8/042 (2013.01); A61K 8/735 (2013.01); A61K 9/06 (2013.01); A61K 31/728 (2013.01); A61Q 19/00 (2013.01); C08J 3/075 (2013.01); C08J 3/244 (2013.01); C08J 2305/08 (2013.01);
Abstract
Efficient cross-linking of hyaluronic acid (HA) is provided by a manufacturing process. In the process, HA is activated by an initial cross-linking in an aqueous solution. Unreacted cross-linking agent is removed from the activated HA. Cross-linking of the activated HA is finalized, without addition of any additional cross-linking agent, in a suspension of a liquid precipitating medium and the activated HA in precipitated form. The resulting cross-linked HA products exhibit high effective cross-linker ratio and other favorable properties, making the products useful as implants and in medical and cosmetic surgery.