The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Feb. 05, 2014
Engmab Ag, Wilen, CH;
Minh Diem Vu, Wollerau, CH;
Klaus Strein, Weinheim, DE;
Ekkehard Moessner, Kreuzlingen, CH;
Ralf Hosse, Cham, CH;
Oliver Ast, Bassersdorf, CH;
Anne Freimoser-Grundschober, Zürich, CH;
Marina Bacac, Zürich, CH;
Tanja Fauti, Zürich, CH;
Christian Klein, Bonstetten, CH;
Pablo Umana, Wollerau, CH;
Samuel Moser, Rotkreuz, CH;
ENGMAB SÀRL, Boudry, CH;
Abstract
A bispecific antibody specifically binding to the two targets human CD3ε and human BCMA, wherein the variable domains of one antibody portion are replaced by each other, and characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said antibody does not alter APRIL-dependent NF-κB activation, BAFF-dependent NF-κB activation, and does not alter NF-κB activation without BAFF and APRIL is useful as a therapeutic agent.