The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Aug. 24, 2015
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Heidi L. Perez, Ewing, NJ (US);
Donna Wei, Belle Mead, NJ (US);
Robert M. Borzilleri, New Hope, PA (US);
Sanjeev Gangwar, Foster City, CA (US);
Gretchen M. Schroeder, Ewing, NJ (US);
Heng Cheng, Foster City, CA (US);
Robert J. Schmidt, Hainesport, NJ (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/65 (2017.01); A61K 38/07 (2006.01); C07K 5/10 (2006.01); C07K 5/078 (2006.01); C07K 5/062 (2006.01); A61K 47/48 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06139 (2013.01); A61K 47/48438 (2013.01); A61K 47/48569 (2013.01); A61K 47/48715 (2013.01); C07K 5/06026 (2013.01); C07K 5/06034 (2013.01); C07K 5/06052 (2013.01); C07K 16/3038 (2013.01); C07K 16/3046 (2013.01);
Abstract
Tubulysin analogs of the formula (I) where R, RR, R, R, R, R, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.