IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10077261 B1

PDFFull Text
Date of Patent:
Sep. 18, 2018

Filed:

Sep. 11, 2015

Imidazolin-5-one derivative useful as fasn inhibitors for the treatment of cancer

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Peter J. Connolly, New Providence, NJ (US);

Gilles C. Bignan, Bridgewater, NJ (US);

Tianbao Lu, Churchville, PA (US);

Michael H. Parker, Chalfont, PA (US);

Donald W. Ludovici, Quakertown, PA (US);

Christophe Meyer, Les Authieux sur le Port Saint Ouen, FR;

Lieven Meerpoel, Beerse, BE;

Karine Smans, Beerse, BE;

Christian Rocaboy, Murcia, ES;

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:
Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01);
Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L, a, b, m, n, R, R, R, R, and Rare defined herein.

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