The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
May. 11, 2017
Applicant:
Global Blood Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Zhe Li, San Diego, CA (US);
Nathan Guz, Half Moon Bay, CA (US);
Yiyang Shao, Beijing, CN;
Julieana Cocuz, Neutraubling, DE;
Markus Frieser, Maxhuette-Haidhof, DE;
George Petros Yiannikouros, Florence, SC (US);
Liang Liao, South San Francisco, CA (US);
Assignee:
Global Blood Therapeutics, Inc., South San Francisco, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07C 47/575 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07C 47/575 (2013.01); C07B 2200/13 (2013.01);
Abstract
Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.