The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Dec. 01, 2015
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventors:
Frank Gupton, Midlothian, VA (US);
Alex Martin, Richmond, VA (US);
Ali Siamaki, Richmond, VA (US);
Katherine Belecki, Richmond, VA (US);
Assignee:
Virginia Commonwealth University, Richmond, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 235/20 (2006.01); C07D 403/04 (2006.01); B01J 23/44 (2006.01); B01J 21/18 (2006.01); B01J 31/22 (2006.01); B01J 31/24 (2006.01); B01J 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 235/20 (2013.01); B01J 21/18 (2013.01); B01J 23/44 (2013.01); B01J 31/2295 (2013.01); B01J 31/2409 (2013.01); B01J 35/0006 (2013.01); C07D 403/04 (2013.01); B01J 2231/4211 (2013.01); B01J 2531/824 (2013.01); B01J 2531/842 (2013.01);
Abstract
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.