The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Mar. 04, 2016
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Marc Wong, San Carlos, CA (US);
Liliana T. Yee, San Francisco, CA (US);
Amy Lim, Palo Alto, CA (US);
Chris B. Fong, San Leandro, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/573 (2006.01); C12N 9/02 (2006.01); C12N 9/90 (2006.01); C07K 1/22 (2006.01); C07K 16/40 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); C07K 1/22 (2013.01); C07K 16/40 (2013.01); C12N 9/0051 (2013.01); C12N 9/90 (2013.01); C12Y 108/04002 (2013.01); C12Y 503/04001 (2013.01); A61K 38/00 (2013.01); G01N 2333/90212 (2013.01); G01N 2333/99 (2013.01);
Abstract
The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.