The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Nov. 16, 2016
Applicant:
National University Corporation Chiba University, Chiba, JP;
Inventor:
Naoto Yamaguchi, Chiba, JP;
Assignee:
National University Corporation Chiba University, Chiba, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 1/30 (2006.01); C12Q 1/6886 (2018.01); G01N 21/64 (2006.01); G01N 21/27 (2006.01); G01N 21/17 (2006.01); G01N 21/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/68 (2013.01); G01N 21/27 (2013.01); G01N 21/6428 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01); G01N 21/00 (2013.01); G01N 2021/1765 (2013.01); G01N 2021/6439 (2013.01);
Abstract
A method for quantitatively evaluating chromatin structural changes using pixel imaging of the nucleus is provided. Pixel imaging of the nucleus can include capturing one or more images of a nucleus of one or more nucleic acid stain treated cells. The stain intensity can be measured by quantitating the intensity. The mean and/or standard deviation of stain intensity per pixel can be used to determine chromatin condensation levels or chromatin structural change.