The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Feb. 16, 2012
Yun Yen, Arcadia, CA (US);
Qiang Liu, Upland, CA (US);
Fouad Kandeel, Duarte, CA (US);
Kevin Ferreri, Duarte, CA (US);
Steve S. Sommer, Duarte, CA (US);
Rasha Shehatta, Duarte, CA (US);
Yun Yen, Arcadia, CA (US);
Qiang Liu, Upland, CA (US);
Fouad Kandeel, Duarte, CA (US);
Kevin Ferreri, Duarte, CA (US);
Steve S. Sommer, Duarte, CA (US);
Rasha Shehatta, Duarte, CA (US);
CITY OF HOPE, Duarte, CA (US);
Abstract
The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.