The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Mar. 27, 2015
Applicant:
Rheinische Friedrich-wilhelms-universität Bonn, Bonn, DE;
Inventors:
Marion Goldeck, Bonn, DE;
Jasper Van Den Boorn, Bonn, DE;
János Ludwig, Göttingen, DE;
Christine Schuberth-Wagner, Siegburg, DE;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C07H 21/02 (2006.01); A61K 9/00 (2006.01); C12N 15/11 (2006.01); C12N 15/117 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/0021 (2013.01); C07H 21/02 (2013.01); C12N 15/111 (2013.01); C12N 15/117 (2013.01); C12N 15/1137 (2013.01); C12N 2310/17 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3513 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/3517 (2013.01); C12N 2310/3527 (2013.01); C12N 2310/3533 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.