The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 11, 2018

Filed:

Feb. 28, 2013
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Sangeeta N. Bhatia, Lexington, MA (US);

Kelly R. Stevens, Cambridge, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 11/04 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2015.01); C12N 11/08 (2006.01); C12N 11/10 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 11/04 (2013.01); A61K 35/12 (2013.01); C12N 5/0012 (2013.01); C12N 5/0062 (2013.01); C12N 5/0671 (2013.01); C12N 11/08 (2013.01); C12N 11/10 (2013.01); G01N 33/5005 (2013.01); C12N 2533/76 (2013.01); C12N 2535/10 (2013.01);
Abstract

The invention features an 'inverse patterning' or 'Intaglio-Void/Embed-Relief Topographic (In VERT) molding' manufacturing process for generating high-resolution three-dimensional (3D) multi-cellular microstructures in distinct cellular compartments of a single hydrogel. The platform has general utility in the development of engineered tissues for human therapies, drug testing, and disease models. Additionally, the platform can serve as a model system for studying 3D cell-cell interactions in fields as diverse as stem cell biology to the development of cancer therapeutics.


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