The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 11, 2018

Filed:

Apr. 14, 2014
Applicants:

Centre National DE LA Recherche Scientifique, Paris, FR;

Universite D'aix-marseille, Marseilles, FR;

Inventors:

Eric Chabriere, Marseilles, FR;

Mikael Elias, Florange, FR;

Julien Hiblot, Marseilles, FR;

Didier Raoult, Marseilles, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A01N 63/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); A01N 63/00 (2013.01); C12Y 301/08001 (2013.01); A61K 38/00 (2013.01); C12Y 301/08 (2013.01);
Abstract

Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.


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