The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 11, 2018

Filed:

Oct. 21, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Mark E. Scott, Edmonton, CA;

David Guerin, Natick, MA (US);

Danielle Molinari, Brookline, MA (US);

Sam Kattar, Sudbury, MA (US);

Peter Fuller, Wakefield, MA (US);

Christopher Dinsmore, Newton, MA (US);

Norman Kong, Jiangsu, CN;

Yunfeng Bai, Beijing, CN;

Jianmin Fu, Beijing, CN;

Yumei Liu, Beijing, CN;

Zhixiang Zheng, Beijing, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); C07D 471/04 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61K 31/554 (2006.01); A61K 31/541 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 31/4545 (2013.01); A61K 31/538 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 31/554 (2013.01); C07D 471/04 (2013.01);
Abstract

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.


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