The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Aug. 24, 2015
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Merck Canada Inc., Kirkland, CA;
Ashok Arasappan, Bridgewater, NJ (US);
Christopher James Bungard, Lansdale, PA (US);
Jessica L. Frie, Harleysville, PA (US);
Yongxin Han, Needham, MA (US);
Scott B. Hoyt, Hoboken, NJ (US);
Peter J. Manley, Harleysville, PA (US);
Robert S. Meissner, Newton, MA (US);
James J. Perkins, Churchville, PA (US);
Iyassu K. Sebhat, Jersey City, NJ (US);
Robert R. Wilkening, Maplewood, NJ (US);
Kenneth J. Leavitt, Mount Laurel, NJ (US);
Abstract
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, L, X, X, and X, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.