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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10071983 B1

PDFFull Text
Date of Patent:
Sep. 11, 2018

Filed:

Apr. 18, 2016

Activatable fluorogenic compounds and uses thereof as near infrared probes

Applicant:

Ramot AT Tel-aviv University Ltd., Tel-Aviv, IL;

Inventors:

Doron Shabat, Tel-Aviv, IL;

Ronit Satchi-Fainaro, Tel-Aviv, IL;

Assignee:

Ramot at Tel-Aviv University Ltd., Tel-Aviv, IL;

Attorney:
Primary Examiner:

Michael G Hartley

Assistant Examiner:

Jagadishwar R Samala

Int. Cl.
CPC ...
A61K 49/00 (2006.01); C07D 401/14 (2006.01); C09B 23/01 (2006.01); C09B 23/08 (2006.01); C09B 23/12 (2006.01); G01N 33/58 (2006.01); C07D 209/08 (2006.01); C07D 209/12 (2006.01); C07D 213/30 (2006.01); C07D 213/71 (2006.01); C07D 213/76 (2006.01); C07D 213/85 (2006.01); G01N 33/52 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 47/558 (2017.08); A61K 49/0021 (2013.01); A61K 49/0032 (2013.01); A61K 49/0052 (2013.01); A61K 49/0056 (2013.01); C07D 209/08 (2013.01); C07D 209/12 (2013.01); C07D 213/30 (2013.01); C07D 213/71 (2013.01); C07D 213/76 (2013.01); C07D 213/85 (2013.01); C09B 23/0066 (2013.01); C09B 23/086 (2013.01); C09B 23/12 (2013.01); G01N 33/52 (2013.01); G01N 33/582 (2013.01);
Abstract

Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.

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