The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 11, 2018

Filed:

Dec. 22, 2015
Applicants:

Ludwig-maximilians-universität München, München, DE;

Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v., München, DE;

Inventors:

Armin Giese, München, DE;

Uwe Bertsch, Scheuring, DE;

Hans Kretzschmar, Hohenschäftlarn, DE;

Matthias Habeck, München, DE;

Thomas Hirschberger, Stuttgart, DE;

Paul Tavan, München, DE;

Christian Griesinger, Göttingen, DE;

Andrei Leonov, Göttingen, DE;

Sergey Ryazanov, Göttingen, DE;

Petra Frick, München, DE;

Markus Geissen, Buchholz i.d. Nordheide, DE;

Martin H. Groschup, Weitenhagen, DE;

Jens Wagner, München, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/12 (2006.01); A61K 31/4155 (2006.01); A61K 31/4164 (2006.01); A61K 31/42 (2006.01); A61K 31/4245 (2006.01); G01N 33/68 (2006.01); A61K 31/40 (2006.01); A61K 31/415 (2006.01); C07D 207/333 (2006.01); C07D 405/04 (2006.01); C07D 271/06 (2006.01); C07D 261/08 (2006.01); C07D 233/64 (2006.01); C07D 413/04 (2006.01); C07D 231/06 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); A61K 31/40 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4164 (2013.01); A61K 31/42 (2013.01); A61K 31/4245 (2013.01); C07D 207/333 (2013.01); C07D 231/06 (2013.01); C07D 233/64 (2013.01); C07D 261/08 (2013.01); C07D 271/06 (2013.01); C07D 405/04 (2013.01); C07D 413/04 (2013.01); G01N 33/6896 (2013.01); G01N 2800/2828 (2013.01);
Abstract

The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.


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