The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Oct. 02, 2015
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Edward J. Merino, Cincinnati, OH (US);
James Mulloy, Cincinnati, OH (US);
Anish K. Vadukoot, Cincinnati, OH (US);
Mark Wunderlich, Cincinnati, OH (US);
Safnas F. Abdulsalam, Cincinnati, OH (US);
Assignee:
University of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 233/26 (2006.01); A61K 31/167 (2006.01); A61K 45/06 (2006.01); A61K 31/4468 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); C07D 211/58 (2006.01);
U.S. Cl.
CPC ...
C07C 233/26 (2013.01); A61K 31/167 (2013.01); A61K 31/4468 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); C07D 211/58 (2013.01);
Abstract
Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of hydrogen peroxide and are therefore selective anti-cancer therapeutics for cancers associated with elevated reactive oxygen species (ROS). Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.